TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis
These data demonstrate that, during endotoxemia, TLR4 activation in bovine adipocytes triggers lipolysis via prostaglandin E2-dependent mechanisms. In addition, LPS modulates EP receptor expression, resulting in alterations in lipid mobilization. Together, these data provide initial evidence of prostaglandin receptors as possible targets for modulating WAT lipid trafficking during endotoxemia.
Authors
- A.L. Lock (ORCID: https://orcid.org/0000-0002-9282-399X)
- Madison N. Myers (ORCID: https://orcid.org/0000-0001-8567-8694)
- G. Andres Contreras (ORCID: https://orcid.org/0000-0003-4969-2178)
- Jair Parales-Girón (ORCID: https://orcid.org/0009-0001-2780-969X)
- Miguel Chirivi (ORCID: https://orcid.org/0000-0001-6604-2981)
- L C Worden (ORCID: https://orcid.org/0000-0002-2840-8302)
- Ursula Abou-Rjeileh (ORCID: https://orcid.org/0000-0002-9426-6971)
Institutions
- Michigan State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1591210
- Citations
- 5
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 5.60
Funders
- Michigan Alliance for Animal Agriculture
- National Institute of Food and Agriculture