Clinicopathological profile of eosinophilic fasciitis: a retrospective cohort study from a neuromuscular disorder center in China
The "prayer sign" might be an important clinical feature of EF. Perifascicular upregulation of MHC-I and/or MHC-II but negative expression of MxA, with or without PFA, represents a unique pathological phenotype of EF. Most patients show favorable outcome following steroid monotherapy or in combination with immunosuppressants, underscoring the autoimmune pathogenic nature of this disease.
Authors
- Kai Shao (ORCID: https://orcid.org/0000-0003-1563-5722)
- Lining Zhang (ORCID: https://orcid.org/0000-0002-7563-6957)
- Xiaotian Ma
- Bing Zhao (ORCID: https://orcid.org/0000-0001-8814-5930)
- Ying Hou (ORCID: https://orcid.org/0000-0002-7188-3563)
- Chuanzhu Yan (ORCID: https://orcid.org/0000-0001-5698-9960)
- Tingjun Dai (ORCID: https://orcid.org/0000-0003-4928-0421)
- Xiaoyuan Wang (ORCID: https://orcid.org/0000-0002-6002-1589)
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s13075-025-03574-z
- Citations
- 3
- Primary Topic
- Eosinophilic Disorders and Syndromes
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- Qingdao Key Health Discipline Development Fund
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Natural Science Foundation of Qingdao