Validation of CTA-based closed-loop coronary artery flow simulations against intravascular Doppler velocity and pressure measurements
CTA-CFD simulations showed statistically significant correlations for intravascular flows and pressures, whereas no meaningful correlation was observed for velocity. These findings highlight the influence of measurement variability and modeling assumptions. Future studies should consider the inherent uncertainties in CTA-CFD, especially when estimating absolute hemodynamic parameters such as velocity and pressure, and aim to refine boundary conditions and validation strategies to improve accuracy.
Authors
- Ehtisham Mahmud (ORCID: https://orcid.org/0000-0003-2493-8661)
- Belal Al Khiami
- Ryan Reeves (ORCID: https://orcid.org/0000-0001-7887-964X)
- Lawrence Ang (ORCID: https://orcid.org/0000-0002-3206-7432)
- Alison L. Marsden (ORCID: https://orcid.org/0000-0003-1902-171X)
- Andrew M. Kahn (ORCID: https://orcid.org/0000-0002-6677-4215)
- Anahita Abbasnejad Seresti (ORCID: https://orcid.org/0009-0009-4178-380X)
- Muhammad Owais Khan (ORCID: https://orcid.org/0000-0001-5137-1942)
Institutions
- University of Toronto (CA)
- University of California San Diego (US)
- Toronto Metropolitan University (CA)
- Stanford University (US)
Publication Details
- Journal
- Computer Methods and Programs in Biomedicine
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1016/j.cmpb.2025.108868
- Citations
- 3
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Natural Sciences and Engineering Research Council of Canada