The role of FAM111B in the malignant progression and molecular regulation of human glioma through the PI3K/Akt pathway
This is the first study to demonstrate that FAM111B plays a crucial role in the proliferation, migration, and invasion of glioma cells. The malignant phenotype of FAM111B has also been shown to be closely associated with the PI3K/AKT pathway. FAM111B may be a predictive biomarker and a potential therapeutic target for gliomas.
Authors
- Wenhao Zheng (ORCID: https://orcid.org/0000-0002-9618-2456)
- Haiyang Wang (ORCID: https://orcid.org/0000-0002-4020-6690)
- Jianguo Zhu (ORCID: https://orcid.org/0000-0003-0778-7718)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-9330-0728)
- Quan Du (ORCID: https://orcid.org/0000-0002-9871-0718)
- Jianqiang Zhu (ORCID: https://orcid.org/0009-0000-2117-9183)
- Linjie Wang (ORCID: https://orcid.org/0000-0003-3227-9184)
Institutions
- Zhejiang Chinese Medical University (CN)
- Westlake University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Publication Details
- Journal
- Chinese Neurosurgical Journal
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s41016-025-00395-6
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhejiang Traditional Chinese Medicine Administration