Fusobacterium nucleatum downregulated MLH1 expression in colorectal cancer by activating autophagy-lysosome pathway
<i>F. nucleatum</i> reduces MLH1 expression via the lysosomal pathway by butyrate, leading to deficient mismatch repair (dMMR), which may yield therapeutic benefits in CRC patients with microsatellite stability (MSS).
Authors
- Heping Zhang (ORCID: https://orcid.org/0000-0003-3608-2549)
- Tingting Ding (ORCID: https://orcid.org/0000-0002-4537-9451)
- Xingchen Zhu (ORCID: https://orcid.org/0000-0001-8674-5246)
- Hu Liu (ORCID: https://orcid.org/0000-0001-6774-6868)
- Li Zhao (ORCID: https://orcid.org/0000-0003-1576-8787)
- Jing Guo (ORCID: https://orcid.org/0000-0002-3159-584X)
- Yaohui Gao
- Lamei Zhao
- X.P. Cao (ORCID: https://orcid.org/0009-0005-0459-5747)
- Qing Wei
- Michael Wu (ORCID: https://orcid.org/0009-0009-5388-6363)
Institutions
- Beijing University of Chinese Medicine (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Shanghai East Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1586146
- Citations
- 2
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Natural Science Foundation of China