Comprehensive analyses of telomerase component DKC1 and its association with clinical, molecular and immune landscapes in uterine corpus endometrial carcinoma
The present findings unravel genomic alteration- and sex hormone-mediated dysregulation of the telomerase cofactor DKC1 in UCEC tumors, and its upregulation participates actively in the UCEC pathogenesis through tumor-intrinsic and extrinsic mechanisms. DKC1 assessment is useful for patient prognostication and personalized interventions.
Authors
- Chenxi Sun (ORCID: https://orcid.org/0000-0002-1762-0877)
- Huiyang Yuan
- Chengyun Zheng (ORCID: https://orcid.org/0000-0001-6260-297X)
- Dawei Xu (ORCID: https://orcid.org/0000-0003-3141-4524)
- Tiantian Liu (ORCID: https://orcid.org/0009-0006-7463-3216)
- Yang Jiang (ORCID: https://orcid.org/0000-0003-0468-1598)
- Xu Liu (ORCID: https://orcid.org/0000-0002-8501-3403)
- Binggen Li (ORCID: https://orcid.org/0000-0002-2652-8933)
- Chenliu Fan
Institutions
- Karolinska University Hospital (SE)
- Second Hospital of Shandong University (CN)
- Weihai Chest Hospital (CN)
- Weihai Science and Technology Bureau (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fcell.2025.1592135
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81