Engineering of antimicrobial peptide Brevinin-1pl: arginine, lysine, and histidine substitutions enhance antimicrobial-anticancer efficacy with reduced cytotoxicity
These findings demonstrate that strategic amino acid substitutions can optimize the therapeutic potential of AMPs, offering a promising approach to develop peptides with enhanced efficacy and reduced clinical side effects.
Authors
- Mei Zhou (ORCID: https://orcid.org/0000-0003-2576-0252)
- F. R. Zeng
- Yongfei Fang (ORCID: https://orcid.org/0000-0002-3221-8931)
- Lei Wang (ORCID: https://orcid.org/0000-0002-8811-8489)
- Xiaoling Chen (ORCID: https://orcid.org/0000-0002-6932-1983)
- Tao Wang (ORCID: https://orcid.org/0000-0003-3111-2024)
- Yangyang Jiang (ORCID: https://orcid.org/0000-0001-8291-4161)
- Jinwei Zhang
- Tianbao Chen
- Jingkai Wang (ORCID: https://orcid.org/0009-0008-2849-8564)
Institutions
- Queen's University Belfast (GB)
- Integrated Chinese Medicine (China) (HK)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fchem.2025.1579097
- Citations
- 2
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 2.37