ANXA1 promotes intrahepatic cholangiocarcinoma proliferation and growth by regulating glutamine metabolism through GOT1 stabilization
These results suggest that the ANXA1/USP5/GOT1 axis promotes glutamine metabolism and ICC proliferation and growth. Inhibiting ANXA1 alongside glutamine uptake inhibition offers a promising strategy for treating ICC.
Authors
- Yanyu Gong
- Yongning Li (ORCID: https://orcid.org/0000-0003-0912-4694)
- Zhiwei He (ORCID: https://orcid.org/0000-0002-1434-2170)
- Dijie Zheng
- Chao Yu (ORCID: https://orcid.org/0000-0002-9244-9416)
- Hao Wang (ORCID: https://orcid.org/0000-0001-8729-8556)
- Fei Ran Li (ORCID: https://orcid.org/0000-0002-2455-4986)
- Liwen Chen (ORCID: https://orcid.org/0000-0002-7271-2467)
- Changhao Wu (ORCID: https://orcid.org/0009-0001-4294-4275)
- Yazhu Deng
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s13046-025-03400-z
- Citations
- 6
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- National Natural Science Foundation of China