Preclinical NCI-MPACT: prospective modeling of the mutation-based NCI-MPACT clinical trial therapeutic strategy in patient-derived xenograft models
This prospective preclinical study confirmed the modest response rates in the NCI-MPACT clinical trial. Substantial responses to temozolomide suggest that this drug represents an effective treatment for patients with MGMT deficiency, regardless of cancer type.
Authors
- Laura Kuhlmann (ORCID: https://orcid.org/0000-0003-0555-5163)
- Shivaani Kummar (ORCID: https://orcid.org/0000-0001-6906-1627)
- Alice P. Chen (ORCID: https://orcid.org/0000-0002-2919-4326)
- Ming‐Chung Li
- Sergio Y. Alcoser
- Chris Karlovich (ORCID: https://orcid.org/0000-0002-4617-2161)
- Larry Rubinstein (ORCID: https://orcid.org/0000-0002-9720-9737)
- Eric C. Polley (ORCID: https://orcid.org/0000-0002-5152-8740)
- P. Mickey Williams
- James H. Doroshow (ORCID: https://orcid.org/0000-0002-4463-1790)
- Yvonne A. Evrard (ORCID: https://orcid.org/0000-0002-3475-4850)
- Vishnuprabha Rahul Kannan
- Mel Simpson
- Shahanawaz Jiwani (ORCID: https://orcid.org/0000-0002-4717-8637)
- Lindsay Dutko
- Yingdong Zhao (ORCID: https://orcid.org/0000-0002-8514-0293)
- Biswajit Das (ORCID: https://orcid.org/0000-0002-1929-3646)
- Melinda G. Hollingshead (ORCID: https://orcid.org/0000-0002-1207-1397)
- Alida Palmisano (ORCID: https://orcid.org/0000-0002-1859-3719)
- Michael E. Mullendore
- Li Chen (ORCID: https://orcid.org/0000-0002-3965-8833)
- Chih-Jian Lih
- Vivekananda Datta
Institutions
- General Dynamics (United States) (US)
- Oregon Health & Science University (US)
- Chicago Department of Public Health (US)
- University of Chicago (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fonc.2025.1571635
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Cancer Institute