Two major human phenotypes of MICA molecules and their differential activation to NK cells via NKG2D receptor
This study demonstrates the existence of two distinct types of <i>MICA</i> polymorphisms that differentially regulate NKG2D receptor activation and NK cell cytotoxicity. These findings offer new insights into that how genetic variation in MICA may contribute to individual differences in disease susceptibility through immune regulation mechanisms.
Authors
- Leiyan Wei
- Quan Zhu (ORCID: https://orcid.org/0000-0003-1820-4354)
- Yizhou Zou (ORCID: https://orcid.org/0000-0002-9261-1161)
- Rongjiao Liu (ORCID: https://orcid.org/0000-0003-3024-4690)
- Weiguang Luo (ORCID: https://orcid.org/0000-0002-6237-824X)
- Qizhi Luo
- Xiangli Yin
Institutions
- Central South University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1563872
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province