The novel role of Yin Yang 1 in acute rejection of liver allografts through activation of dendritic cells
YY1 promotes DC activation and naïve T cell polarization towards inflammatory phenotypes, thereby contributing to acute rejection in liver transplantation. Targeting YY1 may offer a therapeutic strategy to mitigate acute rejection and improve transplant outcomes. Further research is warranted to explore YY1's regulatory mechanisms and therapeutic potential in liver transplantation.
Authors
- Liping Hong
- Yi Chen (ORCID: https://orcid.org/0000-0003-3262-3627)
- Jie Wang (ORCID: https://orcid.org/0000-0002-7491-7001)
- Hongtao Wang (ORCID: https://orcid.org/0000-0003-1720-7828)
- Lihong Chen (ORCID: https://orcid.org/0000-0002-2302-6890)
- Wubing He (ORCID: https://orcid.org/0009-0002-5187-6339)
Institutions
- Fujian Medical University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1597779
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80