Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment

We conclude that models that control for individual variability in intracranial and ventricular volumes have the potential to minimize discrepancies and variations in structural reports of HIV, improving the diagnostic power of identified patterns and fostering greater consistency across research studies. More importantly, adjusting for LV may not only detect atrophic patterns that could be overlooked in analyses performed without any adjustments, but the outcomes obtained from the adjustments may better explain HIV-associated conditions such as HAND and underlying immunological issues often observed in subjects with HIV treated with combination antiretroviral therapy, considering that the adjustments account for certain aspects of regional interaction.

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Publication Details

Journal
Frontiers in Neurology
Published
2025-05-19
DOI
https://doi.org/10.3389/fneur.2025.1516168
Primary Topic
HIV Research and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment

Han Jin, Peter Shaw, Yifei Han, Benedictor Alexander Nguchu et al.
Frontiers in Neurology
HIV Research and Treatment
article

Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment

Han Jin, Peter Shaw, Yifei Han, Benedictor Alexander Nguchu, Jing Zhao, Jiajun Fan, Yanming Wang, Hongjun Li, Lu Yu
article en

Abstract

We conclude that models that control for individual variability in intracranial and ventricular volumes have the potential to minimize discrepancies and variations in structural reports of HIV, improving the diagnostic power of identified patterns and fostering greater consistency across research studies. More importantly, adjusting for LV may not only detect atrophic patterns that could be overlooked in analyses performed without any adjustments, but the outcomes obtained from the adjustments may better explain HIV-associated conditions such as HAND and underlying immunological issues often observed in subjects with HIV treated with combination antiretroviral therapy, considering that the adjustments account for certain aspects of regional interaction.

Frontiers in NeurologyVol. 16
University of Science and Technology of China (CN), Tianjin University of Technology and Education (CN), Capital Medical University (CN), Wenzhou Medical University (CN), Affiliated Eye Hospital of Wenzhou Medical College (CN), Zhejiang Lab (CN), Beijing YouAn Hospital (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 88%
HIV Research and Treatment
DOIOpen Access PDFOpenAlex
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Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment — Han Jin, Peter Shaw, et al. · Frontiers in Neurology (2025) | TGRS Research Map | TGRS