Elevated adipokines and myokines are associated with fatigue in long COVID patients
Post-COVID-19 fatigue is strongly associated with prior ICU admission and elevated levels of myostatin and irisin, implicating potential myopathic mechanisms in its persistence. The profound impact of fatigue on functional capacity and quality of life highlights the urgent need for further research to elucidate its pathophysiology and develop targeted therapeutic strategies. This study provides critical insights into the interplay between systemic and organ-specific factors contributing to fatigue, offering a foundation for future interventions to improve outcomes in patients with long COVID.
Authors
- Nazareth N. Rocha (ORCID: https://orcid.org/0000-0003-0921-8068)
- Gabriela Samanttha Cavalcanti do Nascimento (ORCID: https://orcid.org/0000-0001-8002-8588)
- Nina Visconti
- Celso Caruso‐Neves (ORCID: https://orcid.org/0000-0002-2415-7753)
- José Roberto Lapa e Silva (ORCID: https://orcid.org/0000-0003-3116-0253)
- Johnatas D. Silva (ORCID: https://orcid.org/0000-0003-4379-4237)
- Fernanda Ferreira Cruz (ORCID: https://orcid.org/0000-0001-9443-3648)
- Patrícia R. M. Rocco (ORCID: https://orcid.org/0000-0003-1412-7136)
- Fernanda Carvalho de Queiroz Mello (ORCID: https://orcid.org/0000-0003-3250-6738)
- Camila Marinelli Martins (ORCID: https://orcid.org/0000-0002-6430-2687)
- Caio Vettorazzi Barboza Menário
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal Fluminense (BR)
- Instituto Federal do Rio de Janeiro (BR)
- Universidade Estadual de Ponta Grossa (BR)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3389/fmed.2025.1547886
- Citations
- 2
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro