Prognostic impact of ER-staining patterns and heterogeneity of ER positive HER2 negative breast cancer
This study emphasizes the importance of recognizing heterogeneity within the ER-int subtype. Identifying distinct ER staining patterns and prognostic significance of TILs and transcriptome in ER-int tumors suggests the need for individualized treatment strategies for Island subtype.
Authors
- Yuko Takano (ORCID: https://orcid.org/0000-0002-3753-7683)
- Takahiro Ichikawa (ORCID: https://orcid.org/0000-0002-2545-5410)
- Yoshiko Akita (ORCID: https://orcid.org/0009-0001-7333-5448)
- Madoka Iwase (ORCID: https://orcid.org/0000-0002-4423-4023)
- Toyone Kikumori
- Satoko Shimada
- Tomoki Ebata (ORCID: https://orcid.org/0000-0002-8247-7050)
- Norikazu Masuda (ORCID: https://orcid.org/0000-0002-7302-0278)
- Ravi Velaga (ORCID: https://orcid.org/0009-0002-5962-0266)
- Dai Takeuchi
Institutions
- Kyoto University (JP)
- Nagoya University Hospital (JP)
- Nagoya University (JP)
Publication Details
- Journal
- Breast Cancer
- Published
- 2025-05-18
- DOI
- https://doi.org/10.1007/s12282-025-01716-4
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Nagoya University
- Moonshot Research and Development Program