A Retrospective Study on Pharmacotherapeutic Outcomes in Colorectal Cancer Patients at Tertiary Care Hospital

Introduction:Colorectal cancer is the third most common cancer worldwide, accounting for approximately 10% of all cancer cases and is the second leading cause of cancer-related deaths worldwide.In our literature review we have noted some studies which are done to analyse the different clinical outcomes & disease prognosis of patients with CRC treated with FOLFOX chemotherapy based on different mutation patterns.Surgery and chemotherapy have long been the first choices for cancer patients. Aim:1. To study the various patterns of drug therapy in colorectal cancer Patients. To Understand the disease severity, Prognosis and the treatment outcomes in CRC patientsMethod: A Retrospective, observational and single centered study was conducted in hospital to study the various patterns of drug therapy in colorectal cancer patients. Results:In our study Where N=200, 146 underwent surgery, 77 were treated with chemotherapy and 33 received radiation therapy.The Patients diagnosed with CRC 18 were cured with the surgeries; 15 Patients received neoadjuvant chemotherapy and 62 patients received adjuvant chemotherapy.In this study 35 patients developed the recurrence at different sites. Conclusion:The statistics of our study revealed that there is no significant effect of mutations on the survival rate of colorectal cancer.Patients diagnosed at stage 0, stage I are cured with surgery.Patients at stage III and IV are treated with the appropriate regimens of chemo and radiation therapy.Chance of recurrence occurred after 2-3 years of initial treatment.