Simultaneous Estimation of Metoclopramide Hydrochloride and Dexamethasone Sodium Phosphate Using Vierodt’s Method

The objective of the study is to develop simple, precise, authentic and cost effective analytical method for the estimation of antiemetic drugs according to ICH guidelines.The working standard solutions of metoclopramide hydrochloride and dexamethasone sodium phosphate were scanned in UV from the range of 200-400 nm where the max or the absorption maximum of metoclopramide hydrochloride and dexamethasone sodium phosphate was 273 nm and 241.60 are respectively.The isobestic point was 260 nm.The UV method is developed by using 8-16g/ml metoclopramide hydrochloride and 6-12g/ml dexamethasone sodium phosphate.In simultaneous equation method correlation coefficient of metoclopramide hydrochloride was 0.9994.Dexamethasone sodium phosphate shows correlation coefficient of 0.9962.Developed methods are validated as per ICH guidelines.