Formulation and Evaluation of Gastro Retentive Floating Microspheres of Gliclazide

Gliclazide, an oral hypoglycemic agent employed in the management of Type 2 diabetes, poses challenges in achieving sustained release and optimal bioavailability due to its short half-life and variable absorption.This study aimed to develop and characterize Gliclazide-loaded floating microspheres as a gastro retentive drug delivery system.Ionotropic gelation methods were used with hydroxypropyl methylcellulose (HPMC K100M) and Xanthan gum as a polymer, and calcium carbonate as an agent that is gas-forming.An FTIR compatibility study lies in range of 4000-400 cm-1 revealed no significant alteration in the characteristic peaks of Gliclazide and polymer, suggesting their compatibility.The microspheres were assessed for particle size, yield, buoyancy, drug content, swelling index, morphology, and in vitro drug release.The micromeritic examination of the prepared formulations falls within the specified range, demonstrating favorable flow characteristics.Optimized formulations exhibited spherical morphology, particle sizes within the desired range (100-700 m), and percentage yield exceeding 80%.Drug content was consistent throughout all the formulations.In vitro dissolution studies in simulated gastric fluid revealed sustained drug release of 70.05% after 6 hours, with formulations showcasing extended floating behavior.SEM analysis confirmed the spherical shape with smooth surface morphology and structural integrity of the microspheres.These findings indicate the potential of Gliclazide-loaded floating microspheres as an effective platform for prolonged drug release and enhanced gastric retention, offering a promising strategy for optimizing Gliclazide therapy in diabetes management.