Multi-omics analysis of glycolytic reprogramming and ROS dynamics in host-specific responses to Salmonella Typhi infection in mice
S. Typhi infection induces metabolic reprogramming in the host, characterized by a redirected glycolytic flux and altered pyruvate metabolism. This metabolic shift enhances ROS production and modulates the immune response. These findings yield novel insights into host-specific strategies employed by S. Typhi and highlight the significance of metabolic remodeling in immune defense, thereby presenting potential therapeutic targets for combating typhoid fever.
Authors
- Tiansheng Zhang (ORCID: https://orcid.org/0000-0002-8977-6117)
- Yonghe Bai (ORCID: https://orcid.org/0009-0001-5906-2527)
- Xiaoe He (ORCID: https://orcid.org/0000-0002-4323-1381)
- Jiayin Guo (ORCID: https://orcid.org/0000-0001-6963-8617)
- Qian Wang (ORCID: https://orcid.org/0000-0002-9674-4914)
- Jing Yang (ORCID: https://orcid.org/0000-0002-9581-5979)
- Hongchuan Jin (ORCID: https://orcid.org/0000-0002-6697-3097)
- Hui Sun (ORCID: https://orcid.org/0000-0002-1152-5932)
- Han Xiao (ORCID: https://orcid.org/0000-0003-4124-9411)
- Zhiyuan Liu (ORCID: https://orcid.org/0000-0002-4253-1753)
- Yan Wang (ORCID: https://orcid.org/0000-0001-9417-0550)
- Yana Li (ORCID: https://orcid.org/0000-0002-3386-9090)
- Wenxiu Liu (ORCID: https://orcid.org/0000-0002-8835-5556)
- Shengmin Xiao
- Dandan Ding
Institutions
- Shandong University of Aeronautics (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-18
- DOI
- https://doi.org/10.1016/j.jare.2025.05.027
- Citations
- 4
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 4.65