Integrating Au@MOF@COF nanocomposites for electrochemical aptasensing of trace oxytetracycline
Developing efficient electrochemical aptasensors is one of the effective methods to address the thorny issue of antibiotic abuse that poses a threat to human health. Functional materials are crucial for improving detection performance. Combining the advantages of gold (Au) nanoparticles, metal-organic frameworks (MOFs), and covalent organic frameworks (COFs), a multivariate Au@MOF@COF nanocomposite is designed and synthesized to immobilize aptamers for electrochemical aptasensing of trace oxytetracycline (1.0 × 10<sup>–4</sup> – 0.1 ng mL<sup>–1</sup>) with great sensitivity, good repeatability, fine stability, and remarkable selectivity. Especially, quantitative detection and analysis of oxytetracycline can be achieved in real milk samples using this aptasensor.
Authors
- Xinyue Yang (ORCID: https://orcid.org/0000-0003-3928-5261)
- Hongming He (ORCID: https://orcid.org/0000-0001-5535-8825)
- Fuxing Sun (ORCID: https://orcid.org/0000-0002-6869-4649)
- Zixuan Xie (ORCID: https://orcid.org/0000-0002-4921-2309)
- Shan Zhang (ORCID: https://orcid.org/0009-0000-5819-634X)
- Xinyi Wang (ORCID: https://orcid.org/0000-0001-7527-838X)
- Ping Li (ORCID: https://orcid.org/0000-0001-8285-8921)
- Jiyang Li (ORCID: https://orcid.org/0000-0002-6580-710X)
- Jia Liu (ORCID: https://orcid.org/0000-0002-2679-6874)
Publication Details
- Journal
- Nano Research
- Published
- 2025-05-18
- DOI
- https://doi.org/10.26599/nr.2025.94907590
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University