Cognitive Stability Among Plasma p-tau 181 Negative Individuals: A 5-year Analysis of the Multidomain Alzheimer Prevention Trial Study
Cognitive performance in older people with negative plasma p-tau181 levels remains stable over a 5-year period. This may suggest that older age alone, in the absence of positive biomarkers for brain pathology (or frailty), is not associated with cognitive decline. Frailty may increase vulnerability to the neuropathological burden associated with Alzheimer's disease.
Authors
- Pierre Skolil
- Bertrand Perret (ORCID: https://orcid.org/0000-0001-7568-445X)
- Alain Bonafé (ORCID: https://orcid.org/0000-0002-9187-1375)
- Jacques Darcourt (ORCID: https://orcid.org/0000-0002-6143-713X)
- Lauréane Brigitte
- François Cotton (ORCID: https://orcid.org/0000-0003-0046-2478)
- Françoise Lala
- Sophie Guyonnet (ORCID: https://orcid.org/0000-0001-9527-5282)
- Thierry Dantoine
- Philippe Robert
- Laurent Molinier (ORCID: https://orcid.org/0000-0002-4068-0181)
- Gabor Abellán van Kan (ORCID: https://orcid.org/0009-0005-9607-9722)
- Christelle Cantet
- Colette Blatge
- Catherine Faisant
- Audrey Gabelle (ORCID: https://orcid.org/0000-0002-7648-9194)
- Franck Le Duff (ORCID: https://orcid.org/0000-0002-7899-491X)
- Thierry Voisin (ORCID: https://orcid.org/0000-0002-4320-5183)
- Isabelle Carrié
- Isabelle Marcet
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Patrick Manckoundia (ORCID: https://orcid.org/0000-0002-5518-9803)
- Fleur Delva (ORCID: https://orcid.org/0000-0001-5594-5405)
- Kristel Sudres
- Sandrine Andrieu (ORCID: https://orcid.org/0000-0002-1142-770X)
- Sylvie Belleville (ORCID: https://orcid.org/0000-0002-1046-1818)
- Marie-Laure Pader
- Davide Angioni (ORCID: https://orcid.org/0000-0003-3253-2522)
- Hélène Villars (ORCID: https://orcid.org/0000-0001-7668-1808)
- Jean‐Pierre Salles (ORCID: https://orcid.org/0000-0002-0941-8951)
- Nicola Coley (ORCID: https://orcid.org/0000-0002-1671-824X)
- Jacques Monteil (ORCID: https://orcid.org/0000-0002-7255-709X)
- Cécilia Marelli (ORCID: https://orcid.org/0000-0002-9543-6311)
- Pierre Payoux (ORCID: https://orcid.org/0000-0002-1374-1620)
- Audrey Zueras
- Federico Bellelli
- Nicolas Lebrun (ORCID: https://orcid.org/0000-0002-0043-3821)
- Brigitte Gilbert (ORCID: https://orcid.org/0000-0001-6720-0224)
- Stéphanie Roth (ORCID: https://orcid.org/0000-0001-5415-1718)
- Philipe de Souto Barreto (ORCID: https://orcid.org/0000-0002-8860-425X)
- Sylvie Caspar‐Bauguil (ORCID: https://orcid.org/0000-0003-2682-0704)
- Carole Dufouil (ORCID: https://orcid.org/0000-0003-2442-4476)
- Alain Pesce
- Nadège Costa (ORCID: https://orcid.org/0000-0002-1185-3960)
- Pascale Olivier (ORCID: https://orcid.org/0000-0002-1801-9581)
- Karim Bennys (ORCID: https://orcid.org/0000-0003-1363-0143)
- Ileana Désormais (ORCID: https://orcid.org/0000-0003-3728-568X)
- Olivier Rouaud (ORCID: https://orcid.org/0000-0001-9767-8421)
- Claire Gervais (ORCID: https://orcid.org/0000-0003-2433-5537)
- Céline Caillaud
- Christophe Morin (ORCID: https://orcid.org/0000-0002-4387-3261)
- Fabrice Bonneville (ORCID: https://orcid.org/0000-0003-2950-8759)
- François Chollet
- Noëlle Cardinaud
- Hélène Derumeaux
- Claire Vinel (ORCID: https://orcid.org/0000-0003-3329-321X)
- Charlotte Dupuy
- Christelle Cantet
- Marc Bonnefoy (ORCID: https://orcid.org/0000-0001-9186-3714)
- Jacques Touchon
- Jean‐François Dartigues
- Alexandra Foubert
- Bruno Vellas
- Marie Chupin A (ORCID: https://orcid.org/0009-0009-5696-6000)
- Sandrine Cerda
- F. Ricolfi
- Pierre Jean Ousset
- Yves Rolland
- Pierre-Jean Ousset
- Serge Bordes
- Danièle Begorre
- Christian Carpuat
- Lynda Touati
- Marie-France Basset
- Lawrence Bories
- Christine Malick-Loiseau
- Flavien Terracol
- Françoise Desclaux
- Isabelle Saulnier
- Anne Hitzel
- Evelyne Franon
- Carole Badufle
- Sophie Marilier
- Marie Paule Bonceour Martel
- Jean-Pierre Clément
- Francine Fontaine
- Michel Zanca
- Pascale Rebaudet
- Sandrine Louchart
- Aurélia Romano
- Françoise Hugon
- Yannick Gasnier
- Cécile Laubarie-Mouret
- Nadège Barro-Belaygues
- Michael Li Yung Tong
- Sylvie Chaillou
- Sophie Peiffer
- Claire Gédéon
- Stéphane Chanalet
- Cécile Pays
- Dominique Dubois (ORCID: https://orcid.org/0000-0001-7347-5304)
- Evelyne Cazaban-Campistron
- Catherine Burdet
- Emeline Combrouze
- Laurence Bernard-Bourzeix
- Valérie Quipourt
- Ali Bouhayia
- Jean-François Mangin
- Khaled Khales
- Christophe Cognard
- Sébastien Gonfrier
- Pierre Livet
- Marie-Agnès Picat
- Samira Misbah El Idrissi
- Stéphanie Willebois
- Corinne Costes
- Valérie Faure
- Bruno Lapoujade
- Jean-François Lefebvre
Institutions
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- University of Milan (IT)
- Sahlgrenska University Hospital (SE)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Centre de Recherches en Cancérologie de Toulouse (FR)
- Institute for Advanced Study in Toulouse (FR)
- University of Gothenburg (SE)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-05-18
- DOI
- https://doi.org/10.1093/gerona/glaf113
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47