Comparison of Nicotine and Selected Flavoring Contents Between Tobacco-Free and Tobacco-Containing Oral Pouches

This is the first non-industry study to compare nicotine content, release, form, and select flavoring composition between multiple ONPs and OTPs. These findings have implications if any future modified risk claims for ONPs are considered. Although nicotine content was significantly higher in OTPs than in ONPs, the amount of nicotine released from the pouch was very similar between ONPs and OTPs. While many flavoring chemicals present in ONPs and OTPs are generally recognized as safe for oral consumption, their potential oral health risk in ONP and OTP users has not been evaluated and therefore must be monitored and assessed.