Chaperone overexpression boosts heterologous small molecule production in Saccharomyces cerevisiae
The endogenous cytosolic chaperone overexpression library and mating based screening method presented in this report constitute a tool allowing for fast and efficient identification of specific chaperones and chaperone combinations that benefit production of a given SM in S. cerevisiae-based cell factories.
Authors
- Anna L. Vestergaard (ORCID: https://orcid.org/0000-0001-8716-1111)
- Paul Cachera (ORCID: https://orcid.org/0000-0001-6093-6108)
- Uffe Hasbro Mortensen (ORCID: https://orcid.org/0000-0002-7794-7273)
- Wasti Nurani (ORCID: https://orcid.org/0000-0002-2517-7422)
Institutions
- Novo Nordisk Foundation (DK)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s12934-025-02728-7
- Primary Topic
- Plant biochemistry and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovationsfonden
- European Commission
- Novo Nordisk
- Novo Nordisk Fonden