High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation
Our findings indicated that high salt intake represented a risk factor for the development of CP/CPPS as it promoted the differentiation of CD4<sup>+</sup> T cells to Th17 cells through the 5-HIAA/AHR/SGK1/FOXO1 axis, which might be a potential therapeutic target for CP/CPPS.
Authors
- Bangshun Dai (ORCID: https://orcid.org/0000-0002-2316-8135)
- Weikang Wu
- Wenlong Xu (ORCID: https://orcid.org/0000-0002-0091-4238)
- Rui Tan (ORCID: https://orcid.org/0000-0002-7795-1141)
- Y. Xiao
- Chang Yin Liang (ORCID: https://orcid.org/0000-0003-2317-1323)
- Jing Chen (ORCID: https://orcid.org/0000-0003-2434-0010)
- Li Zhang (ORCID: https://orcid.org/0000-0003-2599-952X)
- Xiaobin Wang (ORCID: https://orcid.org/0000-0001-8894-2884)
- Meng Tong (ORCID: https://orcid.org/0000-0003-4832-2490)
- Rui Feng (ORCID: https://orcid.org/0000-0003-0861-443X)
- Binbin Gong
- Cheng Yang (ORCID: https://orcid.org/0000-0002-6969-1968)
Institutions
- Anhui Medical University (CN)
- Southern University of Science and Technology (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-05-18
- DOI
- https://doi.org/10.1186/s40779-025-00607-1
- Citations
- 3
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 5.51
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Anhui Province
- Sanming Project of Medicine in Shenzhen