Mannitol-facilitated entry of vancomycin into the central nervous system inhibits neuroinflammation in a rat model of MRSA intracranial infection by modulating brain endothelial cells
Mannitol may enhance the therapeutic efficacy of vancomycin against intracranial MRSA infection by decreasing the endothelial glycocalyx of the BBB via F-actin depolymerization.
Authors
- Wen Yin (ORCID: https://orcid.org/0000-0002-1393-7682)
- Jiaqi Tang (ORCID: https://orcid.org/0000-0001-5019-9255)
- Shuangming Cai (ORCID: https://orcid.org/0000-0002-7524-8321)
- Hongke Zeng (ORCID: https://orcid.org/0000-0003-3243-4199)
- Hongguang Ding (ORCID: https://orcid.org/0000-0003-4420-5684)
- Mengting Liu
- Ming-Jia Li (ORCID: https://orcid.org/0000-0003-1969-6733)
- Shiying Zhang (ORCID: https://orcid.org/0000-0003-0984-0260)
- Huishan Zhu
- Zhiwei Su
Institutions
- Zhujiang Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
Publication Details
- Journal
- World Journal of Emergency Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5847/wjem.j.1920-8642.2025.057
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00