Vitamin C and N-acetylcysteine promote bovine adipose-derived mesenchymal stem cell proliferation and differentiation via Akt/mTOR/P70S6K signalling pathway for cultured meat production
This research concludes that NAC (2 mM) and VC (200 μM) improved the proliferation, differentiation potential, and stemness by decreasing oxidative stress and senescence, parallelly activating Akt/mTOR/P70S6K signaling pathway, while combined treatment (NAC+VC) enhanced these effects, providing bases for their utilisation to culture fat in cultivated meat production.
Authors
- Sungkwon Park (ORCID: https://orcid.org/0000-0002-7684-9719)
- Sajida Naseem (ORCID: https://orcid.org/0000-0003-3144-1100)
- Huan Hua
- Mei‐Fu Xuan (ORCID: https://orcid.org/0009-0004-8566-4996)
- Qiang Li (ORCID: https://orcid.org/0000-0003-2722-1324)
- Xiangzi Li (ORCID: https://orcid.org/0000-0003-3061-3847)
- Hailong Teng
- Huaina Jin (ORCID: https://orcid.org/0009-0008-3270-8587)
- Abid Manzoor (ORCID: https://orcid.org/0009-0002-3180-8005)
Institutions
- Yanbian University of Science and Technology (CN)
- Yanbian University (CN)
- Sejong University (KR)
Publication Details
- Journal
- Animal Bioscience
- Published
- 2025-05-18
- DOI
- https://doi.org/10.5713/ab.24.0776
- Primary Topic
- Viral Infectious Diseases and Gene Expression in Insects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- People's Government of Jilin Province
- Ministry of Education, Science and Technology