Compressive force-induced succinate production via metabolic reprogramming in periodontal ligament cells promotes orthodontic tooth movement
OTM is accompanied by the increase of succinate in periodontal tissues. Compressive force induces metabolic reprogramming in PDLCs, leading to enhanced succinate production. Succinate promotes macrophage migration and osteoclast differentiation via the SUCNR1 axis, ultimately facilitating orthodontic tooth movement. These findings provide a new potential therapeutic target for regulating periodontal tissue remodeling during orthodontic treatment.
Authors
- Jiahong Shi (ORCID: https://orcid.org/0000-0001-5794-4449)
- Meng Zhu (ORCID: https://orcid.org/0000-0001-6157-8840)
- Houxuan Li (ORCID: https://orcid.org/0000-0002-3798-8628)
- Lang Lei (ORCID: https://orcid.org/0000-0003-2892-040X)
- Yú Chen (ORCID: https://orcid.org/0000-0003-2491-3974)
- Lulu Wang (ORCID: https://orcid.org/0000-0002-8002-6483)
- Lutong Shan
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Progress in Orthodontics
- Published
- 2025-05-18
- DOI
- https://doi.org/10.1186/s40510-025-00563-5
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing Medical Science and Technique Development Foundation