When Neisseria meningitidis Strikes an Immunocompetent Host and Purpura Fulminans Results

Purpura fulminans (PF) is a rapidly progressive, life-threatening condition marked by ecchymotic, tender, and symmetric skin lesions, often resulting from disseminated intravascular coagulation (DIC) secondary to infectious or non-infectious etiologies. PF usually occurs in immunocompromised hosts and is associated with a high mortality rate. Here, we highlight a case of an elderly immunocompetent woman with <i>Neisseria meningitis-mediated</i> DIC and subsequent PF. Her case underscores the importance of early intervention in managing this rare but deadly condition in order to ensure optimal survival outcomes. Early intervention for PF with DIC includes the timely administration of antibiotics, steroids, and anticoagulants, along with addressing the underlying consumptive coagulopathy.

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Publication Details

Journal
Cureus
Published
2025-05-18
DOI
https://doi.org/10.7759/cureus.84350
Primary Topic
Bacterial Infections and Vaccines
Type
article
Field-Weighted Citation Impact
0.00
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article

When Neisseria meningitidis Strikes an Immunocompetent Host and Purpura Fulminans Results

Andy Li, Prachi Saxena, Aye M Thida, Jordonna Brown et al.
Cureus
Bacterial Infections and Vaccines
article

When Neisseria meningitidis Strikes an Immunocompetent Host and Purpura Fulminans Results

Andy Li, Prachi Saxena, Aye M Thida, Jordonna Brown, Ekenedilichukwu N Nnadi
article en

Abstract

Purpura fulminans (PF) is a rapidly progressive, life-threatening condition marked by ecchymotic, tender, and symmetric skin lesions, often resulting from disseminated intravascular coagulation (DIC) secondary to infectious or non-infectious etiologies. PF usually occurs in immunocompromised hosts and is associated with a high mortality rate. Here, we highlight a case of an elderly immunocompetent woman with <i>Neisseria meningitis-mediated</i> DIC and subsequent PF. Her case underscores the importance of early intervention in managing this rare but deadly condition in order to ensure optimal survival outcomes. Early intervention for PF with DIC includes the timely administration of antibiotics, steroids, and anticoagulants, along with addressing the underlying consumptive coagulopathy.

CureusVol. 17(5)
State University of New York (US), SUNY Downstate Health Sciences University (US)
Zero hunger
Openalex Percentile: Top 90%
Bacterial Infections and Vaccines
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