An integrative approach prioritizes the orphan GPR61 genomic region in tissue-specific regulation of chronotype
Our findings reveal pleiotropic genetic factors influencing chronotype and ease of getting up, emphasizing <i>GPR61</i>'s rs12044778 and nearby genes like <i>AMIGO1</i> and <i>ATXN7L2</i>. These insights advance our understanding of circadian preferences and suggest potential therapeutic interventions.
Authors
- Jonathan S. Williams (ORCID: https://orcid.org/0000-0001-7152-765X)
- Hanna M. Ollila (ORCID: https://orcid.org/0000-0002-5302-6429)
- Richa Saxena (ORCID: https://orcid.org/0000-0002-6634-2041)
- Herman Taylor
- Cynthia Tchio (ORCID: https://orcid.org/0000-0003-2516-010X)
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- University of Helsinki (FI)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Institute for Molecular Medicine Finland (FI)
- Morehouse School of Medicine (US)
Publication Details
- Journal
- SLEEP Advances
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1093/sleepadvances/zpaf030
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Institutes of Health