Dual targeting of <i>CD155</i>/<i>TIGIT</i> and <i>PD-L1</i>/<i>PD-1</i> immune checkpoints potentiates NK cell-mediated cytotoxicity in medulloblastoma
These data propose a translatable and novel immunotherapeutic strategy for children diagnosed with subgroups Sonic Hedgehog and Group 3 MB.
Authors
- Max Koppers (ORCID: https://orcid.org/0000-0002-7751-1082)
- Morten Quist (ORCID: https://orcid.org/0000-0002-0983-957X)
- Julia Klein (ORCID: https://orcid.org/0000-0002-0707-311X)
- Michael Y. Schakelaar
- Jelle Wesseling (ORCID: https://orcid.org/0000-0002-8940-2676)
- Toine ten Broeke
- Alicia Perzolli (ORCID: https://orcid.org/0000-0003-1302-0943)
- Niels Bovenschen (ORCID: https://orcid.org/0000-0002-8526-4456)
- Jan Meeldijk
- Friso Calkoen (ORCID: https://orcid.org/0000-0001-9059-0929)
- Celeste Koster
- Sven van Kempen (ORCID: https://orcid.org/0009-0006-5079-0639)
- Thijs Koorman (ORCID: https://orcid.org/0000-0002-6064-3353)
- Matthijs Monnikhof
- Marcel Kool (ORCID: https://orcid.org/0000-0002-6557-5468)
- Jasper van der Lugt (ORCID: https://orcid.org/0000-0002-8186-338X)
- Sandra Crnko (ORCID: https://orcid.org/0000-0002-3962-1408)
- Francesco Valzano
- Kim Clevers
- Chris Meulenbroeks
- Aniello Federico
- Heggert G Rebel
- Emma W Pijnappel
- Aimee Selten
- Maureen Fredriks
- Vela Kaludjerovic
- Daniëlle S C Maassen
- Alba Montoro Canelo
Institutions
- German Cancer Research Center (DE)
- Utrecht University (NL)
- Heidelberg University (DE)
- University Medical Center Utrecht (NL)
- Hopp Children's Cancer Center Heidelberg (DE)
- Princess Máxima Center (NL)
- Amsterdam University Medical Centers (NL)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf099
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Deutsches Krebsforschungszentrum
- Universiteit Utrecht
- Deutschen Konsortium für Translationale Krebsforschung