First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate
In patients with pulmonary sarcoidosis, initial treatment with methotrexate was noninferior to that with prednisone with regard to the change from baseline to week 24 in the percentage of the predicted FVC. Differences in the side-effect profile between methotrexate and prednisone may inform shared decision making by providers and patients about the appropriate treatment approach. (Funded by the Dutch Lung Foundation; PREDMETH ClinicalTrials.gov number, NCT04314193.).
Authors
- Pascal Wielders (ORCID: https://orcid.org/0000-0003-3719-5967)
- Vivienne Kahlmann (ORCID: https://orcid.org/0000-0001-6003-7380)
- Rémy L.M. Mostard (ORCID: https://orcid.org/0000-0002-0127-2855)
- H.N.A.J. van Rijswijk
- Hubertus F.J.M. Koopman (ORCID: https://orcid.org/0000-0001-5091-1724)
- E.R. Marges (ORCID: https://orcid.org/0000-0003-1829-533X)
- Brigitte A.H.A. Bogaarts
- Marcel Veltkamp (ORCID: https://orcid.org/0000-0001-7973-1604)
- Peter Iwan Bonta (ORCID: https://orcid.org/0000-0002-0429-4988)
- M. Overgaauw
- Marlies Wijsenbeek (ORCID: https://orcid.org/0000-0002-4527-6962)
- Daan W. Loth (ORCID: https://orcid.org/0000-0003-1260-9326)
- Stefan Walen (ORCID: https://orcid.org/0000-0001-6563-1119)
- H. Krämer (ORCID: https://orcid.org/0000-0002-3785-0258)
- Jan C. Grutters (ORCID: https://orcid.org/0000-0003-3670-8097)
- L. Moonen
- Catharina C. Moor (ORCID: https://orcid.org/0000-0002-5295-2877)
- Jan van der Maten
- René Kerstens
- Montse Janssen Bonás
- M. Wagenaar
- Maria J. Overbeek
- Esther J. Nossent
Institutions
- Centraal Bureau voor de Statistiek (NL)
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Catharina Ziekenhuis (NL)
- Medisch Spectrum Twente (NL)
- Erasmus MC (NL)
- Medisch Centrum Leeuwarden (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Medisch Centrum Haaglanden (NL)
- St. Antonius Ziekenhuis (NL)
- OLVG (NL)
- Amphia Ziekenhuis (NL)
- Martini Ziekenhuis (NL)
- VieCuri Medisch Centrum (NL)
- Zuyderland Medisch Centrum (NL)
- ERN GUARD-Heart (NL)
- Isala (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- Jeroen Bosch Ziekenhuis (NL)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-05-18
- DOI
- https://doi.org/10.1056/nejmoa2501443
- Citations
- 37
- Primary Topic
- Sarcoidosis and Beryllium Toxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 43.08
Funders
- Lung Foundation Netherlands