Michaelis-Menten Kinetics using Adaptive Gaussian Process Regression

The Michaelis-Menten kinetics model plays a fundamental role in enzyme kinetics studies due to its ability to describe the rate of enzymatic reactions. However, traditional approaches to determine the kinetic parameters face limitations in accurately capturing the underlying complex biochemical dynamics. This paper addresses the current challenges in Michaelis-Menten kinetics research by leveraging Adaptive Gaussian Process Regression, a machine learning technique capable of adaptively learning complex nonlinear patterns. Our innovative approach offers a more flexible and data-driven method for estimating kinetic parameters, enhancing the accuracy and robustness of the model. By presenting a comprehensive analysis of the proposed method's performance, this study contributes to advancing the understanding and application of Michaelis-Menten kinetics in biochemical research.

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Publication Details

Journal
Journal of Computational Biology and Medicine
Published
2024-08-15
DOI
https://doi.org/10.71070/jcbm.v4i1.97
Primary Topic
Gaussian Processes and Bayesian Inference
Type
article
Field-Weighted Citation Impact
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article

Michaelis-Menten Kinetics using Adaptive Gaussian Process Regression

Min-seo Lee, Jihoon Kim, Soo‐Young Park
Journal of Computational Biology and Medicine
Gaussian Processes and Bayesian Inference
article

Michaelis-Menten Kinetics using Adaptive Gaussian Process Regression

Min-seo Lee, Jihoon Kim, Soo‐Young Park
article en

Abstract

The Michaelis-Menten kinetics model plays a fundamental role in enzyme kinetics studies due to its ability to describe the rate of enzymatic reactions. However, traditional approaches to determine the kinetic parameters face limitations in accurately capturing the underlying complex biochemical dynamics. This paper addresses the current challenges in Michaelis-Menten kinetics research by leveraging Adaptive Gaussian Process Regression, a machine learning technique capable of adaptively learning complex nonlinear patterns. Our innovative approach offers a more flexible and data-driven method for estimating kinetic parameters, enhancing the accuracy and robustness of the model. By presenting a comprehensive analysis of the proposed method's performance, this study contributes to advancing the understanding and application of Michaelis-Menten kinetics in biochemical research.

Journal of Computational Biology and MedicineVol. 4(1)
Sunchon National University (KR), Institute of Mathematics and Mathematical Modeling (KZ), Kyungnam University (KR)
Openalex Percentile: Top 73%
Gaussian Processes and Bayesian Inference
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Michaelis-Menten Kinetics using Adaptive Gaussian Process Regression — Min-seo Lee, Jihoon Kim, et al. · Journal of Computational Biology and Medicine (2024) | TGRS Research Map | TGRS