Spatial transcriptomics through Principal Component Analysis
Spatial transcriptomics, a cutting-edge technology that enables the high-resolution mapping of gene expression within tissues, is becoming increasingly popular in the field of biological research. The ability to visualize gene expression in its spatial context is essential for understanding complex biological processes. However, current research in spatial transcriptomics faces challenges such as large data volumes and the need for effective analytical methods. In this paper, we address these challenges by proposing a novel approach using Principal Component Analysis (PCA) to analyze spatial transcriptomic data. Our innovative method not only simplifies the analysis process but also provides valuable insights into the spatial relationships of gene expression patterns. This study contributes to advancing the field of spatial transcriptomics by presenting a more efficient and effective method for analyzing complex spatial gene expression data.
Authors
- Yuki Tanaka
- Taro Yamamoto (ORCID: https://orcid.org/0000-0001-8294-8716)
- Akira Suzuki
Institutions
- Kagawa University (JP)
- Matsuyama University (JP)
- Ehime University (JP)
- Shizuoka Institute of Science and Technology (JP)
Publication Details
- Journal
- Journal of Computational Biology and Medicine
- Published
- 2025-02-06
- DOI
- https://doi.org/10.71070/jcbm.v5i1.69
- Primary Topic
- Gene expression and cancer classification
- Type
- article
- Field-Weighted Citation Impact
- 0.00