Synthesis, Diagnoses and Biological Evaluation of New Ligand Derived from Mesalazine and acetyl isothiocyanate with their metal ion complexes

Mesalazine ligand (ML) having the isothiocyanate has been synthesis via reaction of mesalazine with acetyl isothiocyanate using absolute ethanol to give 5-(3-acetylthioureido)-2-hydroxybenzoic acid (ML) ligand in one step, then the two step involved the reaction of (ML) ligand with ionic salts as Ni (II), Cu (II), Co (II), and Zn(II) via two sites for coordination (O, S) to prepared five complexes in good yield. The synthesized ligand and complexes were branded using (FTIR), (1H-NMR,13CNMR), UV-vis spectroscopy, and (CHNS), as well as molar conductivity, magnetic susceptibility of complexes in their solid state, and atomic absorption, in addition to measuring melting points. From the results, we note that the molar ratio (M:L) is (1:2) for all the prepared complexes. From our results, the expected geometry for all chelating complexes is octahedral. The same synthesis of five complexes (ML1 - ML5) was used to measure biological activity via two types of bacteria, and showed excellent results compared to the Ciprofloxacin drug.