Clinical Study of Premature Canities and Its Association with Hemoglobin, Serum Calcium, Vitamin B12, Vitamin D and Ferritin Levels

Background: Premature canities (PHG), or early-onset hair graying, is a multifactorial condition influenced by genetic, environmental, and nutritional factors.Among these, biochemical deficiencies-particularly in vitamin B12 and vitamin D-have gained attention for their possible role in hair pigmentation.This study aims to assess the association between various biochemical markers and the severity of PHG.Methods: A cross-sectional study was conducted over 1.5 years at KD Medical College Hospital, Mathura.Seventy individuals aged 15-30 years presenting with premature graying were enrolled.Data collection included detailed history, grading of PHG severity, and biochemical investigations, including hemoglobin, ferritin, calcium, vitamin B12, and vitamin D. Statistical analysis was performed to evaluate correlations between these markers and PHG severity.Results: The mean age of participants was 21.475.94years, with the highest prevalence in the 15-20 age group.A positive family history of PHG was found in 57.14% of cases, and 40% reported stress as a contributing factor.Notably, serum vitamin B12 (mean 212.34179.00pg/mL; r=-0.61;p=0.01) and vitamin D levels (mean 18.4115.39ng/mL; r=-0.52;p=0.01) showed a statistically significant inverse correlation with PHG severity.Hemoglobin, ferritin, and calcium levels did not show a significant association.Conclusion: Vitamin B12 and vitamin D deficiencies are significantly associated with the severity of premature canities.Early nutritional assessment and supplementation may serve as effective strategies for managing PHG.Further studies are warranted to explore additional genetic and environmental contributors.