Outcome and Survival Following Surgical Resection of Low-Grade Glioma: A Clinical Study

Background: Low-grade gliomas (LGGs) are slow-growing brain tumors with the potential for malignant transformation.Surgical resection remains the primary treatment approach, with the extent of resection serving as a critical prognostic factor.Methods: This prospective study analyzed 40 patients with histologically confirmed LGG who underwent surgical resection between October 2024 and December 2024 at Agartala Government Medical College and GB Pant Hospital.Demographic data, the extent of resection, postoperative Karnofsky Performance Status (KPS), tumor progression, and malignant transformation were recorded.Patients were followed up for up to 3 months postoperatively.Results: Of the 40 patients, 25 underwent gross total resection (GTR) and 15 had subtotal resection (STR).At the 3-month followup, 90% of GTR patients showed improved KPS compared to 53% in the STR group.Tumor progression was observed in 16% of GTR cases and 47% of STR cases.The malignant transformation occurred in 8% of GTR and 33% of STR patients.The 3-month survival rate was significantly higher in the GTR group (92%) compared to the STR group (67%). Conclusion:The extent of resection plays a significant role in influencing survival and progression outcomes in LGG.Gross total resection is associated with better postoperative recovery, reduced recurrence, and prolonged survival.Maximal safe resection should be prioritized, and supported by advanced neurosurgical tools.