Comparison of Efficacy of Fractional Carbon Dioxide Laser Versus Microneedling with Platelet-Rich Plasma in the Treatment of the Striae

Background: Striae distensae (stretch marks) are common dermatological concerns resulting from excessive skin stretching, leading to dermal collagen and elastin disruption.This study aims to compare the clinical efficacy and safety of Fractional CO2 Laser (FCL) and Microneedling with Platelet-Rich Plasma (MN-PRP) for the treatment of striae.Methods: An observational comparative study was conducted over 1.5 years at KDMCHRC.A total of 60 patients (age 18-40 years) were recruited and divided into two equal groups: Group A (treated with FCL) and Group B (treated with MN-PRP).Baseline and post-treatment assessments included digital photography, width measurement of striae, physician assessment score, patient satisfaction score, improvement in skin texture and overall appearance, and occurrence of side effects.The treatments were performed over 3 sessions at monthly intervals, and patients were followed up for 16 weeks.Results: Fractional CO2 Laser demonstrated superior early results in terms of width reduction and improved texture at 4 and 12 weeks (p<0.05).However, by 16 weeks, both modalities showed comparable efficacy.Post-inflammatory hyperpigmentation (PIH) was more common in the FCL group (23.33%) than in the MN-PRP group (10%).Conclusion: FCL provides a faster improvement, but MN-PRP offers a safer alternative for patients prone to PIH.Both modalities are effective, and patient selection should consider individual risk factors and treatment goals.