Quality of life among children with Multisystem Inflammatory Syndrome (MIS-C) at Vietnam National Children’s Hospital in 2022: A Case series study

Objectives: Multisystem inflammatory syndrome in children (MIS-C) after COVID-19 can affect children’s well-being and adversely impact their quality of life, espe-cially for children in developing countries such as Vietnam. Therefore, this study aims to describe the clinical characteristics and the corresponding quality of life of MIS-C patients admitted to the Vietnam National Children’s Hospital (VNCH) in 2022. Methods: This cross-sectional study utilized a preceding study to collect data regard-ing MIS-C patients’ characteristics, clinical features, and quality of life after treat-ment. The quality of life was assessed using PedsQL version 4.0 instrument. While mean and standard deviation was used to describe quantitative variables, qualitative variables were shown using frequency and percentage. Results: There were 245 participants in this study. A majority of participants were male and 8-12 years old. For symptoms, conjunctivitis occurred in most patients, which accounted for more than 70% across all age groups. In terms of quality of life, the mean score of physical aspects were highest among the age groups with the score equal to approximately 96.8 points. Patients who had experienced rash, lymphade-nopathy, vomiting, and abdominal pain had low mean scores in all aspects of quality of life. Conclusions: Children with MIS-C at the VNCH showed similar clinical symptoms with international studies. After being treated, patients with certain MIS-C-related clinical symptoms showed different effects each dimension in quality of life. Keywords: MIS-C, COVID-19, children, quality of life