STIM1 as a Potential Biomarker for Increased Risk of Community-Acquired Pneumonia in Asthmatic Children: A Prospective Cohort Study

Aim: To study the correlation between serum STIM1 level and high susceptibility to pneumonia in children with asthma. Methods: A total of 116 children hospitalized at our facility as the study subjects, which were categorized into three groups: pneumonia complicated with asthma group, pneumonia group, asthma group. 30 healthy children were selected as a blank group. The concentrations of serum STIM1 were measured and compared across all groups. Results: The study measured serum STIM1 concentrations (pg/ml) in the pneumonia complicated with asthma group , pneumonia group , asthma group and blank group, which were (398.6 ± 17.54), (349.9 ± 17.84), (360.2 ± 35.88), and (418.1 ± 14.40), respectively. The data showed that there were statistical differences in serum STIM1 concentration in different conditions (P < 0.05). Conclusions: STIM1 is involved in the occurrence and development of bronchial asthma and CAP, and related to CAP with high susceptibility to asthma.