Plasma amino acids after human milk fortification and associations with growth in preterm infants
It is unknown how human milk fortification affects plasma amino acid concentrations, in turn influencing growth patterns in very preterm infants. We show that a fortifier based on bovine colostrum induces higher amino acid concentrations than a conventional fortifier. Fortification-induced increments in amino acid concentrations associated with gestational age, birth weight and head growth, but with small effect sizes and limited relation to body weight or length growth. Plasma amino acid concentrations are influenced by fortification of human milk in early life, but have limited practical application as predictors of body growth and health in individual very preterm infants.
Authors
- Per Torp Sangild (ORCID: https://orcid.org/0000-0002-5462-7760)
- Gerrit van Hall (ORCID: https://orcid.org/0000-0002-2519-8127)
- Martin Bo Rasmussen (ORCID: https://orcid.org/0000-0002-4578-6663)
- Allan Stensballe (ORCID: https://orcid.org/0000-0002-9888-1955)
- Lise Aunsholt (ORCID: https://orcid.org/0000-0003-0965-429X)
- Tik Muk (ORCID: https://orcid.org/0000-0002-7907-5421)
- Gitte Zachariassen (ORCID: https://orcid.org/0000-0003-4440-2362)
- Azra Leto
- Kristine Holgersen (ORCID: https://orcid.org/0000-0002-3141-5685)
- Susanne Soendergaard Kappel (ORCID: https://orcid.org/0000-0002-2023-298X)
Institutions
- University of Copenhagen (DK)
- University of Southern Denmark (DK)
- Aalborg University Hospital (DK)
- Odense University Hospital (DK)
- Rigshospitalet (DK)
- Institute of Clinical Research (GB)
- Sino-Danish Centre for Education and Research (CN)
- Aalborg University (DK)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-05-18
- DOI
- https://doi.org/10.1038/s41390-025-04126-6
- Citations
- 2
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.24