A Single-Cell Atlas Reveals Characteristics of Pan-Cancer Brain Metastases

Major Finding: Brain metastases that arise from various primary sites characteristically harbor chromosomal instability and an immunosuppressive stromal/immune composition.Approach: A comprehensive single-cell transcriptomic atlas of pan-cancer human brain metastases was constructed.Impact: These shared characteristics and dependencies of brain metastases may be targeted therapeutically.

Publication Details

Journal: Cancer Discovery
Published: 2025-01-01
DOI: https://doi.org/10.1158/2159-8290.cd-rw2025-043
Primary Topic: Mathematical Biology Tumor Growth
Type: article
Field-Weighted Citation Impact: 0.00

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article

A Single-Cell Atlas Reveals Characteristics of Pan-Cancer Brain Metastases

Jan 1, 2025

Cancer Discovery

Mathematical Biology Tumor Growth

article

A Single-Cell Atlas Reveals Characteristics of Pan-Cancer Brain Metastases

January 1, 2025article en

Abstract

Cancer Discovery

Good health and well-being

Openalex Percentile: Top 87%

Mathematical Biology Tumor Growth

DOI Source OpenAlex

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A Single-Cell Atlas Reveals Characteristics of Pan-Cancer Brain Metastases · Cancer Discovery (2025) | TGRS Research Map | TGRS