Toxicity study of TEoS-DAZA, a chemical precursor for functional liver imaging with PET/CT
Administration of a thousandfold clinical dose of TEoS-DAZA in rats did not cause any observable adverse events. An injectable solution of [<sup>68</sup>Ga]Ga-TEoS-DAZA containing 100 µg of the precursor is safe for clinical application to humans from the pharmacological point of view. Subsequent dosimetry studies need to be undertaken to reveal any radiation related toxicity.
Authors
- Robert Klopfleisch (ORCID: https://orcid.org/0000-0002-6308-0568)
- Julia Greiser (ORCID: https://orcid.org/0000-0002-3779-6298)
- Martin G. Freesmeyer (ORCID: https://orcid.org/0000-0002-6462-3851)
- Markus Hecht
- Beatrice Engert
- Roman Föll
- Rebecca Steens
Institutions
- Robert Koch Institute (DE)
- Klinikum Altenburger Land (DE)
- Inflarx (Germany) (DE)
- Vertically Integrated Systems (Germany) (DE)
- Jena University Hospital (DE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1186/s41181-025-00342-x
- Citations
- 2
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Friedrich-Schiller-Universität Jena
- Universitätsklinikum Jena