Characteristics and treatment outcome in a prospective cohort of 639 advanced high-grade digestive neuroendocrine neoplasms (NET G3 and NEC). The NORDIC NEC 2 study
Survival was shorter than expected in this unique population-based cohort of advanced digestive HG-NEN, likely due to inclusion of elderly and patients with poor PS. Several novel prognostic factors were identified for NEC and NET G3. An initial sub-effective platinum-based treatment for NET G3 could not be compensated by later-line treatment.
Authors
- Anna Sundlöv (ORCID: https://orcid.org/0000-0003-1565-3496)
- Elizaveta Mitkina Tabaksblat
- Eva Hofsli (ORCID: https://orcid.org/0000-0001-9856-4880)
- Halfdan Sørbye (ORCID: https://orcid.org/0000-0002-7132-6214)
- Geir Olav Hjortland (ORCID: https://orcid.org/0000-0003-3454-7461)
- Hege Elvebakken (ORCID: https://orcid.org/0000-0001-7458-4836)
- Jörg Aßmus (ORCID: https://orcid.org/0000-0002-1688-8556)
- Anne Couvelard (ORCID: https://orcid.org/0000-0002-6316-1210)
- Johanna Svensson (ORCID: https://orcid.org/0000-0003-3292-7719)
- Aurel Perren (ORCID: https://orcid.org/0000-0002-6819-6092)
- Eva Tiensuu Janson (ORCID: https://orcid.org/0000-0002-1649-4880)
- Herish Garresori (ORCID: https://orcid.org/0000-0002-8811-7523)
- Christian Kersten (ORCID: https://orcid.org/0000-0002-5691-2944)
- Ulrich Knigge (ORCID: https://orcid.org/0000-0001-5930-0903)
- Morten Ladekarl (ORCID: https://orcid.org/0000-0002-0182-1228)
- Seppo W. Langer (ORCID: https://orcid.org/0000-0001-9732-9192)
- Lene Weber Vestermark
- Per Pfeiffer (ORCID: https://orcid.org/0000-0002-2925-0586)
- Inger Marie Bowitz Lothe (ORCID: https://orcid.org/0000-0002-4741-8119)
- Siren Morken (ORCID: https://orcid.org/0009-0003-8676-772X)
Institutions
- University of Bern (CH)
- Uppsala University (SE)
- University of Copenhagen (DK)
- Oslo University Hospital (NO)
- Aalborg University Hospital (DK)
- Stavanger University Hospital (NO)
- Haukeland University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Rigshospitalet (DK)
- Hospital of Southern Norway (NO)
- Ålesund Hospital (NO)
- St Olav's University Hospital (NO)
- Skåne University Hospital (SE)
- Hôpital Bichat-Claude-Bernard (FR)
- University of Bergen (NO)
- Aalborg University (DK)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1038/s41416-025-03054-w
- Citations
- 18
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 24.38
Funders
- Aarhus Universitet
- Aarhus Universitetshospital
- Aalborg Universitet
- Universitetet i Bergen
- Aalborg Universitetshospital
- Haukeland Universitetssjukehus
- Ipsen
- Klinisk Institut, Aalborg Universitet