CORRELATION OF SARCOPENIA WITH DIABETES IN CKD V PRE DIALYSIS

Introduction: Sarcopenia, which refers to the loss of both muscle mass and strength, is present among CKD stage V pre-dialysis patients, especially those with diabetes, and results in worse prognoses. Objective:  The purpose of the present study was also to determine the prevalence of sarcopenia and its relation to diabetes in CKD stage V pre-dialysis patients and the effect on muscular strength. Materials and Method:  This quasi-experimental study was conducted at Ali Fatima Hospital, Bhobatian Chowk, Raiwind Road, Lahore, Pakistan, from October, 2023 to March, 2024, and included 90 patients with CKD stage V with eGFR<15 ml/min/1.73m². The dynamometer assessed handgrip strength at baseline and before 3 months of the creation of arteriovenous fistula (AVF). Diabetes mellitus was diagnosed with the help of medical records. Results:  Mean handgrip strength also reduced from 21.00 ± 7.35 kg to 19.22 ± 7.92 kg post-AVF (p<0.001). Handgrip strength was significantly lower in diabetic patients than in non-diabetic patients, 18. 45 ± 7.61 kg for people with diabetes, while for non-diabetics, it was 20.07 ± 8.23 kg (p=0.042). Diabetic patients who exhibited handgrip strength of less than 20 kg was 68.1% while that of non-diabetic patients was 51.2% (p=0.039). Conclusion:  Diabetes was found to harm sarcopenia in pre-dialysis CKD stage V patients, and there is a need to develop interventions.