To assess the Alvarado score's role in suspected acute appendicitis cases with histopathological correlation and relevance to the Suburban Indian Population

Background: Acute appendicitis is one of the most common emergencies, especially among young surgeons, and in such cases, which must be operated on as an emergency, to prevent any morbidity that may arise, in children and the elderly. In this study, we compare the validity of the Alvarado Score&#39;s role with the specimens&#39; histopathology findings after surgery in the decision-making in acute appendicitis. Objectives: To compare and evaluate the reliability of Alvarado in the diagnosis of acute appendicitis in correlation with the histopathology report in sub urban population. Methodology: This prospective Observational study conducted with study population of 100 patients who underwent appendectomy with provisional acute appendicitis at Karpaga Vinayaga Institute of Medical Sciences & Research Centre. The clinical, imaging, and blood investigations of these patients with a provisional diagnosis of appendicitis were used. These patients were evaluated based on the Alvarado score and correlated with histopathological findings. Results: A total of 100 patients were included in the study, of which 62 were males and 38 females, at score of 7 or more, appendicitis was confirmed in 70 of the one hundred study population. Patients, while at scores < 7 appendicitis was confirmed in 30% of the patients. The sensitivity was 93.9%, the specificity was 72.8%, the positive predictive value was 98.4% and the negative predictive value was 44.4%. In the present study, negative appendectomy rate was 9.8% Conclusions: The Alvarado score is a very effective tool in preoperative clinical decision-making, helping to reduce the negative appendectomy rate. Ultrasound imaging helps confirm preoperative diagnosis and early intervention, with postoperative confirmation by histopathology results.