Atrial electrical alterations with intact cardiac structure and contractile function in a mouse model of an HCM-linked ACTN2 variant
The Het M228T mouse model demonstrated atrial electrical alterations that occurred independently of any overt cardiac structural or functional remodelling. These findings may support the causative role for atrial electric phenotypes identified in a subset of patients carrying the variant.
Authors
- Katja Gehmlich (ORCID: https://orcid.org/0000-0003-4019-1844)
- Maya Noureddine (ORCID: https://orcid.org/0009-0001-1890-5962)
- Chris Denning (ORCID: https://orcid.org/0000-0003-0802-8617)
- Siobhan Loughna (ORCID: https://orcid.org/0000-0002-3277-1438)
- Christopher O’Shea (ORCID: https://orcid.org/0000-0003-3030-7364)
- Sophie Broadway‐Stringer (ORCID: https://orcid.org/0000-0003-1657-5442)
- Davor Pavlović (ORCID: https://orcid.org/0000-0002-3171-3551)
- Fiyaz Mohammed (ORCID: https://orcid.org/0000-0002-9022-0132)
- Abbie Hayes
- Bethany A I Jones
Institutions
- University of Nottingham (GB)
- University College Birmingham (GB)
- British Heart Foundation (GB)
- University of Warwick (GB)
- University of Oxford (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology Plus
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1016/j.jmccpl.2025.100455
- Citations
- 1
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Wellcome Trust
- British Heart Foundation
- Animal Free Research UK
- Medical Research Council