Outer membrane vesicles of Porphyromonas gingivalis impede bone regeneration by inducing ferroptosis via the Hippo-YAP signaling pathway
This study shows that a Pg microbiota imbalance inhibits bone regeneration by secreting OMVs from Pg to induce ferroptosis in BMSCs. Mechanically, we illustrated that OMVs induce ferroptosis through the Hippo-YAP pathway. These findings might provide a new insight and potential therapeutic target to promote bone regeneration under oral microbiota imbalance.
Authors
- Xinyao Zhang (ORCID: https://orcid.org/0000-0003-4113-8092)
- Hao Cui
- Lei Qian (ORCID: https://orcid.org/0000-0001-5476-4426)
- Xinghong Luo (ORCID: https://orcid.org/0000-0002-0386-3827)
- Tingting Ning (ORCID: https://orcid.org/0000-0002-9986-8023)
- Dandan Ma (ORCID: https://orcid.org/0000-0003-4484-9455)
- Xianghui Zou (ORCID: https://orcid.org/0000-0002-3523-2413)
- Yan Chen (ORCID: https://orcid.org/0000-0001-8857-4911)
- Yanzhen Wang (ORCID: https://orcid.org/0000-0002-9986-0777)
- Shenglong Tan
- Shuoling Chen
Institutions
- Guangdong Province Stomatological Hospital (CN)
- Stomatology Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1186/s12951-025-03457-0
- Citations
- 8
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 9.21
Funders
- National Natural Science Foundation of China
- Southern Medical University