m6A-lncRNA landscape highlights reduced levels of m6A modification in glioblastoma as compared to low-grade glioma
Overall, we provide evidence that m6A lncRNAs are strongly modulated in gliomas, representing biologically distinct subgroups. Ten novel differentially methylated lncRNAs were identified in gliomas, which might exert regulatory role in glioma cells. These findings may provide a basis for further deeper research on the role of m6A lncRNAs in gliomas.
Authors
- Rytis Stakaitis (ORCID: https://orcid.org/0000-0001-5946-1731)
- Rugile Dragunaite
- Daina Skiriutė (ORCID: https://orcid.org/0000-0002-2032-7161)
- Amit Sharma (ORCID: https://orcid.org/0000-0002-2216-5389)
- Giedrius Steponaitis (ORCID: https://orcid.org/0000-0001-9747-6272)
- Arimantas Tamašauskas (ORCID: https://orcid.org/0000-0002-1698-6957)
Institutions
- Lithuanian University of Health Sciences (LT)
- University Hospital Bonn (DE)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1186/s10020-025-01254-x
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Aarhus Universitet
- Lietuvos Mokslo Taryba