Identification of clinical and pathologic features associated with extranodal extension in patients with HPV-mediated oropharyngeal squamous cell carcinoma
Increased count of involved lymph nodes, size of largest involved lymph node, and presence of perineural invasion in patients with HPV(+)OPSCC are strongly associated with increased odds of ENE. These data suggest that ENE presence can be reliably predicted using the number and size of involved nodes. Such a predictive model could prove a useful tool in informing treatment strategies for HPV(+)OPSCC patients prior to surgical resection of involved lymph node(s) and those without sufficient pathologic ENE data from prior excisional biopsies.
Authors
- Linda X. Yin (ORCID: https://orcid.org/0000-0001-8515-2051)
- Eric J. Moore (ORCID: https://orcid.org/0000-0003-1103-6212)
- Harry E Fuentes (ORCID: https://orcid.org/0000-0002-7837-8359)
- Kathryn M. Van Abel (ORCID: https://orcid.org/0000-0003-0513-4203)
- Samip Patel (ORCID: https://orcid.org/0000-0003-1575-4043)
- Jeffrey Graves (ORCID: https://orcid.org/0000-0003-3347-0546)
- Tissiana Vallecillo (ORCID: https://orcid.org/0000-0003-3095-4369)
- Danelle Rolle-McFarland (ORCID: https://orcid.org/0000-0001-9393-6294)
- Samir H. Patel (ORCID: https://orcid.org/0000-0002-8251-574X)
- Brennan Olson (ORCID: https://orcid.org/0000-0003-2803-5363)
- Jeffrey R. Janus (ORCID: https://orcid.org/0000-0002-5324-0740)
- Joaquín J. García
- David M. Routman (ORCID: https://orcid.org/0000-0002-2768-003X)
- Homan Mohammadi (ORCID: https://orcid.org/0000-0001-7471-643X)
- Aaron Bogan
- Jeannie Daniel
- Mauricio E. Gamez (ORCID: https://orcid.org/0000-0002-0001-1653)
- M.A. Neben-Wittich
- Brent A. Chang (ORCID: https://orcid.org/0000-0001-5821-4640)
- Ashish V. Chintakuntlawar (ORCID: https://orcid.org/0000-0002-2907-6522)
- Chadi Nimeh Abdel‐Halim (ORCID: https://orcid.org/0000-0003-3029-6204)
- Scott C. Lester (ORCID: https://orcid.org/0000-0001-5264-9811)
- Daniel L. Price (ORCID: https://orcid.org/0000-0003-3398-0562)
- Kendall T Tasche
- Katharine A. Price
- Jean Claude Rwigema
- Michael L. Hinni
- L.A. McGee (ORCID: https://orcid.org/0000-0003-1890-0237)
- Adam Holtzmann
Institutions
- Mayo Clinic (US)
- Odense University Hospital (DK)
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Oral Oncology
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1016/j.oraloncology.2025.107308
- Citations
- 2
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.70
Funders
- Center for Clinical and Translational Science, Mayo Clinic