Integrating single-cell with transcriptome-proteome Mendelian randomization reveals colorectal cancer targets
By integrating single-cell data, transcriptomic data, proteomic data and GWAS data for MR analysis, we identified CTSF, PCSK7, LYZ, LMAN2L as potential targets for colorectal cancer.
Authors
- Xiaojie Huang (ORCID: https://orcid.org/0000-0002-5045-9202)
- Jieying Wen (ORCID: https://orcid.org/0009-0002-7771-2586)
- Ziming Zhu (ORCID: https://orcid.org/0000-0001-6819-5754)
- Jing Zhou (ORCID: https://orcid.org/0000-0002-0578-8074)
- Yongfeng Huang (ORCID: https://orcid.org/0009-0000-8579-832X)
- Xiaofeng Li (ORCID: https://orcid.org/0000-0002-4115-3287)
- Hao Li (ORCID: https://orcid.org/0000-0002-1767-6475)
- Xuedong Han
- Song Wang
- Xiaoqian Zhao
- Yunlong Sun (ORCID: https://orcid.org/0009-0008-3380-4706)
- Shanshan Wang
- Tao Zhang
- Xinyue Zhang (ORCID: https://orcid.org/0009-0001-0428-4616)
- Qiaoling Chen (ORCID: https://orcid.org/0009-0008-1381-5811)
- W. N. Lan (ORCID: https://orcid.org/0000-0001-6607-772X)
- Xin Yao (ORCID: https://orcid.org/0009-0006-4256-413X)
- Shuang Li (ORCID: https://orcid.org/0000-0003-4073-6461)
Institutions
- Guangxi University of Chinese Medicine (CN)
- First People's Hospital of Chongqing (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1007/s12672-025-02636-7
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81