Tissue-resident microbiota signature in nasopharyngeal carcinoma
This study developed and validated the applicability of a four-bacteria signature as a prognostic tool for NPC prognostication. Integrated multi-omics analysis further uncovered that the tumour immune microenvironment was perturbed by tissue-resident microbiota, which might pave the way towards the era of microbiota-targeted precision medicine for NPC. Video Abstract.
Authors
- Chunqiao Gan
- Wei Jiang (ORCID: https://orcid.org/0000-0001-6534-8612)
- Mingliang Ye (ORCID: https://orcid.org/0000-0002-5872-9326)
- Ying‐Qin Li (ORCID: https://orcid.org/0000-0001-9378-135X)
- Sai-Wei Huang
- Ying-Qing Li (ORCID: https://orcid.org/0000-0001-8187-6714)
- Guan‐Qun Zhou (ORCID: https://orcid.org/0000-0002-7989-4224)
- Jiewen Bai
- Qing‐Mei He (ORCID: https://orcid.org/0000-0002-3973-7566)
- Han Qiao (ORCID: https://orcid.org/0000-0002-0341-2620)
- Jun Ma (ORCID: https://orcid.org/0000-0002-2686-5673)
- Yin Zhao (ORCID: https://orcid.org/0000-0001-7007-2999)
- Ying Sun (ORCID: https://orcid.org/0000-0002-5888-2929)
- Ling‐Long Tang (ORCID: https://orcid.org/0000-0002-8561-1454)
- Na Liu (ORCID: https://orcid.org/0000-0001-8654-3636)
- Sha Gong (ORCID: https://orcid.org/0000-0001-7044-4668)
- Hui Li (ORCID: https://orcid.org/0000-0001-6396-4833)
- Wen‐Fei Li (ORCID: https://orcid.org/0000-0002-5303-4621)
- Jing-Yun Wang (ORCID: https://orcid.org/0000-0003-0322-7756)
- Xi-Rong Tan
- Junyan Li (ORCID: https://orcid.org/0009-0008-1357-6590)
- Ye‐Lin Liang (ORCID: https://orcid.org/0000-0001-6081-109X)
- Sheng‐Yan Huang
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1186/s40168-025-02114-w
- Citations
- 7
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 12.94
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Fundamental Research Funds for the Central Universities
- Sun Yat-sen University Cancer Center
- Basic and Applied Basic Research Foundation of Guangdong Province